North Island College serves a region of about 80,000 square kilometres, including Northern Vancouver Island and the mainland coast from Desolation Sound to Swindle Island. This region encompasses six school districts: Central Coast, Alberni, Comox Valley, Campbell River, Vancouver Island West and Vancouver Island North.

The college operates three major regional campuses: in Campbell River, Comox Valley and Port Alberni. Each regional campus administers several smaller learning centres situated throughout the college region. Students may access a broad range of learning opportunities, which include college preparatory, academic/university transfer, career, vocational and trades training programs.